A new case of congestive heart failure due to amyloid cardiomyopathy is presented by Yuxuan Wang and discussed by Carine, Heather, Dan and Amit. Guest oncology star: Jackie Zimmerman. Flutter moment by Mark Heslin.
Amit and Dr. Zach Il’Giovine learn about multimodality imaging in amyloid from Dr. Paul Cremer at the Cleveland Clinic. On their way to Dr. Cremer’s office, they run into Dr. Eoin Donnellan and discuss some incredible fellow research related to cardiac amyloid from an electrophysiologic perspective. Flutter moment by Brie Lilly, RN
Dan and Carine chat with Dr. Virginia Hahn about her work profiling HFpEF patients via endomyocardial biopsy only to find a significant proportion of patients with unsuspected cardiac amyloid. This is followed by a high yield discussion with Dr. Joban Vaishnav about ATTR cardiac amyloid treatment and management options. Flutter moment by David Ambinder (MS IV).
Amit and Dr. Ashley Bock learn more about cardiac amyloidosis from Dr. Ron Witteles from Stanford. This episode is the fourth and final part of our immersive journey into the jungle of beta-pleated sheets in the heart. Flutter moment by Lois Adamski.
Meet our guest hosts, experts, and flutter contributors!
Yuxuan Wang, MD, PhD
Jackie Zimmerman, MD, PhD
Dr. Jackie Zimmerman completed the Medical Scientist Training Program at University of Alabama School of Medicine. She completed her internal medicine training and served as assistant chief resident (ACS) for the Longcope firm at The Johns Hopkins Hospital. She is currently a medical oncology fellow at Johns Hopkins and investigating tumor-stromal interactions in pancreatic cancer in the lab of Dr Elizabeth Jaffee.
Paul Cremer, MD
Dr. Cremer earned a Bachelor’s degree in molecular biology from Princeton University, Princeton, NJ, and his medical degree from Harvard Medical School, Boston, MA. Following completion of his internal medicine residency at Massachusetts General Hospital, he worked as a physician for two years at the Navajo IHS Chinle Comprehensive Health Care Facility in Chinle, Ariz. He then continued his postdoctoral training with a three-year fellowship in cardiovascular medicine and a subsequent two-year fellowship in advanced cardiovascular imaging, both at Cleveland Clinic. He joined the Cleveland Clinic staff in 2017. He is the director of the Cleveland Clinic CCU. He enjoys swimming and reading fantasy books with his daughters.
Eoin Donnellan, MD
Dr. Eoin Donnellan is a 3rd year Cardiology Fellow at the Cleveland Clinic and all-around nice guy. He received his medical degree from University College Cork in Ireland before heading to the big city to continue his training at the Mater Hospital in Dublin. He completed his Internal Medicine Residency at the Cleveland Clinic and will start EP Fellowship this July. Outside of the hospital he enjoys long nature walks, whispering sweet nothings, searching for the deeper meaning in little things, and watching thought-provoking and highly entertaining television programs such as This is Us and The Bachelor.
Virginia Shalkey Hahn, MD
Dr. Virginia Shalkey Hahn is a fourth-year Cardiology fellow at Johns Hopkins in Baltimore, MD. She earned her medical degree from the Perelman School of Medicine at the University of Pennsylvania, where she stayed for residency. She moved to Johns Hopkins for Cardiology fellowship (after a 1 year hiatus as an ICU hospitalist). During fellowship, she completed 2 years on the NIH T32 Training grant and one year as chief fellow. She feels passionate about translational heart failure research and mothering her 2 young children.
Joban Vaishnav, MD
Dr. Joban Vaishnav completed her undergraduate and medical school training at St. Louis University. She has since been at Johns Hopkins for residency, cardiology fellowship, and advanced heart failure fellowship. Her early research pursuits were in heart failure with preserved ejection fraction. From this, and from her advanced heart failure training, she developed a strong clinical interest and research interest in early diagnosis and treatment of cardiac amyloidosis.
Ronald (Ron) Witteles, MD
Dr. Ronald Witteles is a graduate of Northwestern University where he earned his B.A. in Biology, and of the University of Chicago Pritzker School of Medicine, where he earned his M.D. with Honors. He then moved west to Stanford University where he completed IM residency and Cardiology fellowship training, serving as both Chief Resident and Chief Fellow. He subsequently joined the faculty at Stanford, and is currently appointed as Professor of Medicine (Cardiovascular Medicine). He has served as Program Director for the Stanford University Internal Medicine Residency Training Program for more than 10 years, where he leads a residency program of approximately 140 residents. He is Co-Director of the Stanford Amyloid Center – one of the nation’s largest centers in the country which specializes in the treatment of patients with amyloidosis, and he leads an active research program in this area. He also serves as Co-Director of the Stanford Multidisciplinary Sarcoidosis Program, and he is a national leader in Cardio-Oncology, serving as Associate Editor for the country’s premier journal dedicated to the field, JACC: CardioOncology.
Zachary Il’Giovine, MD
Dr. Zachary Il’Giovine is a general cardiology fellow at the Cleveland Clinic. He received his medical degree from the Wright State University Boonshoft School of Medicine before completing internal medicine training at Duke University. He has clinical interests in advanced heart failure and cardiac critical care. Outside of the hospital he loves playing soccer and spending time with his wife Clare and son Luca.
Ashley Bock, MD
Dr. Ashley Bock earnined her medical degree at the University of Colorado and completed her internal medicine residency training at Duke. From there she came to the Cleveland Clinic for general cardiology fellowship and advanced heart failure training.
Mark Heslin, B.S.
Mark is a current 3rd year medical student at Cooper Medical School of Rowan University in Camden, New Jersey. He completed his undergraduate studies at James Madison University with a degree in biology. Mark will be applying to internal medicine residency programs this upcoming fall with the hope of applying for a cardiology fellowship in the future. His clinical
interests include clinical reasoning and the management of atherosclerotic cardiovascular disease. Outside of medical school, Mark enjoys spending time on Long Beach Island with his friends and family.
Brie Lilly, RN
Brie Lilly is a Cleveland native. She earned her Bachelors of Science in Nursing at Kent State University and then began her career at the Cleveland Clinic shortly after. She worked in the Clinic’s CICU for 3.5 years and is now enjoying expanding her knowledge and love for cardiology as a Cath Lab RN. On her days off, she enjoys spending quality time with her husband, Scott, and her puppy, Renley.
David Ambinder is a 4th year medical student at the University of Maryland and will be starting urology residency this coming July at Westchester Medical Center. He grew up in New York and graduated from Touro College before heading to Baltimore for medical school. He enjoys spending time with his wife Samantha and 3 lovely children.
- AP Cardiology with Rick Ruberg
- AP Cardiology with Dr. Dan Lenihan
- Lee SP, et al. Contemporary Imaging Diagnosis of Cardiac Amyloidosis. J Cardiovasc Imaging, 2019;27:1-10
- Perry R, et al. The Role of Cardiac Imaging in the Diagnosis and Management of Anderson-Fabry Disease. JACC Cardiovasc Imaging, 2019;12:1230-1242
- Motwani M, et al. Evaluating Suspected Cardiac Amyloidosis. JACC: Case Reports, 2019;1:141-145.
- Falk, Rodney, et al. AL (Light-Chain) Cardiac Amyloidosis: A Review of Diagnosis and Therapy. J Am Coll Cardiol, 2016;68:1323-1341.
- Ruberg FL, et al. Transthyretin Amyloid Cardiomyopathy. J Am Coll Cardiol, 2019;73:2872-2891.
- Gertz MA, et al. Pathophysiology and treatment of cardiac amyloidosis. Nature Reviews Cardiology, 2015;12:91-102.
- Donnelly JP, et al. Cardiac amyloidosis: An update on diagnosis and treatment. Cleve Clin J Med, 2017;84:12-26.
- Ternacle J, et al. Aortic Stenosis and Cardiac Amyloidosis. J Am Coll Cardiol, 2019: 74:2638-2651